Designing Organic Reactions Laboratory

S. Okamoto

Sentaro Okamoto
(Professor)

Office: 23-731-1 Ext.: 3856

e-mail: okamos10@kanagawa-u.ac.jp

04/1992, Ph.D., Tokyo Institute of Technology

03/1987, M.S., Tokyo Institute of Technology

T.Yamada

Takeshi Yamada
(Assistant Professor)

Laboratory: 23-731 Ext.: 3855

e-mail: ft102014ps@kanagawa-u.ac.jp

Research Field

Organic Synthesis, Synthetic Organometallic Chemistry, Polymer Chemistry, Application to Developing Pharmaceuticals and Organic Materials.

Research Overview

Development of efficient molecular transformations by using organometallic reagents and catalysts, and design and synthesis of useful biologically active molecules and organic materials.

Research Subjects

  • 1.Homogeneous metal-catalyzed reactions.
  • 2.Organometallic reagents.
  • 3.Organic catalysts.
  • 4.Asymmetric synthesis
  • 5.Synthesis of biologically active natural and artificial compounds for drug discovery.
  • 6.New polymerization methods.
  • 7.Organic molecule-based materials.

Introduction:

We are developing new methods for fine-chemical production based on the specific reactivity of transitionmetals. We are focusing on fourth-period transition metals, such as Ti, Fe, Co, Ni, and Cu, because they are cheap, readily available, and less toxic than other metals. We are applying our methods to synthesizing new analogues of biologically active substances and evaluating their activity as drug candidates. We are also developing new polymerization methods to produce macromolecules with unique optical and electronic properties for new materials.

Publications
  • 1) Synthetic Reactions Using Low-Valent Titanium Reagents Derived from Ti(OR)4 or CpTiX3 (X = O-i-Pr or Cl) in the Presence of Me3SiCl and Mg, The Chemical Record, 2016, 16, 857-872.
  • 2) From Development of Catalysts for Alkyne and Alkyne/Nitrile [2 + 2 + 2] Cycloaddition Reactions to Their Use in Polymerization Reactions, SYNLETT, 2013, 1044-1060.
  • 3) Synthesis of 2,2’-Bipyridines by Transition Metal-Catalyzed Alkyne/Nitrile [2 + 2 + 2] Cycloaddition Reactions, Heterocycles, 2012, 85, 1579-1602.
  • 4) 4) Synthesis of Organotitanium Complexes from Alkenes and Alkynes, and their Synthetic Applications, Chemical Reviews 2000, 100, 2835-2886.
Affiliated Academic Organizations

S. Okamoto:
The Japan Chemical Society, American Chemical Society, The Society of Synthetic Organic Chemistry, Japan, The Kinki Chemical Society Japan, The Society of Polymer Science, Japan

Current members
◯ Professors: 1 ◯ Assistant Professor: 1 ◯ Post-doctors: 1;
◯ Postgraduates: 3 ◯ Undergraduates: 12

Facilities: Laboratory: GC, HPLC, Preparative LC, FT-IR, UV-Vis., PL, React-IR, Glove box, Schlenk line, Plate Reader Assay (TECAN F-200 pro), Resistivity meter, Digital source-meter, Vapor deposition equipment, Spin coater. Department: 400, 500, and 600 MHz NMR (JEOL), X-ray diffraction, CD, Accu-TOF-MS

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