Biomimetic Coordination Chemistry Laboratory

S. Hikichi

Shiro Hikichi
(Professor)

Office: 23-822 Ext.: 3890

e-mail: hikichi@kanagawa-u.ac.jp

03/1995, Ph.D., Tokyo Institute of Technology

03/1992, M.S., Tokyo Institute of Technology 

J. Nakazawa

Jun Nakazawa
(Assistant Professor)

Laboratory: 23-822 Ext.: 3889

e-mail: jnaka@kanagawa-u.ac.jp

03/2007, Ph.D., Kyushu University

03/2004, M.S., Doshisha University

Research Field

Bioinorganic Chemistry, Coordination Chemistry, Catalytic Chemistry.

Research Overview

Development of biomimetic oxidation catalysts based on coordination chemistry.

Research Subjects

  • 1. Researching mechanisms of dioxygen activation and oxidation catalysis on transition metals.
  • 2.Development of biomimetic oxidation processes and artificial oxidation enzymes based on coordination chemistry.

Introduction:

Design and development of coordination compounds that catalyze selective oxygenation of various organic compounds with environmentally friendly reagents (O2, H2O2, etc.) is an attractive but challenging area of green chemistry. In nature, some transition metal-containing enzymes (metalloenzymes) catalyze selective oxidation of hydrocarbons under physiological mild conditions. Therefore, bio-inspired metallocomplex catalysts may be a fruitful approach to green oxidation catalysts.

The following projects are in progress.

(1) Investigation of the reaction mechanism of non-heme metalloenzymes by model complexes.
(2) Design and development of metallocomplex catalysts (homogeneous catalysts and heterogeneous immobilized metallocomplex catalysts) for green oxidation reactions.

Publications
  • 1)F. Oddon, Y. Chiba, J. Nakazawa, T. Ohta, T. Ogura, and S. Hikichi, “Characterization of mononuclear non-heme iron(III)-superoxocomplex with a five-azole ligand set,” Angewandte Chemie International Edition, vol. 54, pp. 7336–7339 (2015).
  • 2)T. Tsuruta, T. Yamazaki, K. Watanabe, Y. Chiba, A. Yoshida, S. Naito, J. Nakazawa, and S. Hikichi, “Mimicking the Active Sites of Non-heme Iron Oxygenases on the Solid Supports of Catalysts: Formation of Immobilized Iron Complexes with Imidazolyl and Carboxylate Ligands, Chemistry Letters, vol. 44, pp. 144–146 (2015).
  • 3)J. Nakazawa, S. Terada, M. Yamada, and S. Hikichi, “Structural characterization and oxidation reactivity of a nickel(II) acylperoxo complex,” Journal of the American Chemical Society, vol. 136, pp. 6010–6013 (2013).
  • 4)S. Hikichi, K. Hanaue, T. Fujimura, H. Okuda, J. Nakazawa, Y. Ohzu, C. Kobayashi, and M. Akita, “Characterization of nickel(II)-acylperoxo species relevant to catalytic alkane hydroxylation by nickel complex with mCPBA,” Dalton Transactions, vol. 42, pp. 3346–3356 (2013).
Affiliated Academic Organizations

S. Hikichi and J. Nakazawa:
Chemical Society of Japan, American Chemical Society, Japan Society of Coordination Chemistry, Catalysis Society of Japan, Society of Biological Inorganic Chemistry.

Current members
◯ Professors: 1 ◯ Assistant Professors: 1
◯ Postgraduates: 3 ◯ Undergraduates: 13

Facilities: FT-IR spectrometer, UV-vis-NIR spectrometer, gas chromatograph, gas chromatography-mass spectrometry system, high-performance liquid chromatography system, glove box, organic solvent purification and dispensing system.

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